MUM1 is one of nuclear transcription factors necessary for development and activation of B lymphocytes. MUM1 belongs to the IRF gene family containing at least 10 widely expressed genes with similar DNA binding motif all involved in regulation of cell growth, transformation and induction of apoptosis as well as development of T-cell immune response. The synonym of MUM1 is Interferon Regulatory Factor 4 (IRF4) .
MUM1 is found mainly in B-cell lymphoma and melanocytic lesions. Significant variation in positivity mainly due to chromosomal translocations involving MUM1 gene among T-cell lymphomas is observed.
MUM1 is useful in a panel with other markers for subclassification of malignant lymphomas and identification of plasma cell differentiation. Particularly MUM1 may be useful for the identification of plasma cell differentiation when morphologic evidence is lacking and Ig light chains are difficult to interpret.
Specifications
Catalog No.
BX50089
Clone No.
BP6094
Application
IHC-P
Subcellular location
Nucleus
Control
Diffuse Large B Cell Lymphoma
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to residues within C-Term of MUM1 was used as an immunogen.
Reference
1.Grossman A , Hans-Willi Mittrücker, Nicholl J , et al. Genomics, 1996, 37(2):0-233.
2.Gaidano G , Carbone A . LEUKEMIA, 2000, 14(4):563-566.