The human CD19 antigen is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily, which initiates a series of biological responses that are likely to be of central importance to B-cell signaling and/or growth regulation and the development of a humoral immune response.CD19 is specifically expressed in normal and neoplastic B cells, as well as follicular dendritic cells. In normal tissues, it is expressed from pre-B cells until the terminal differentiation to plasma cells. And in tumors, its expression is highly conserved on most B cell tumors. It is expressed in most acute lymphoblastic leukemias (ALL), chronic lymphocytic leukemias (CLL) and B cell lymphomas.CD19 is one of the most reliable surface biomarker for B cells and the CD19 monoclonal antibodies have been explored for lymphoma therapy.
Specifications
Catalog No.
BX50041
Clone No.
BP6046
Application
IHC-P
Subcellular location
Membrane
Control
Tonsil
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to CD19 residues within aa456-556 of CD19 was used as an immunogen.
Reference
1.Wang K, et.al, Exp Hematol Oncol. 2012 Nov 29;1(1):36.
2.Hammer O, et.al, MAbs. 2012 Sep-Oct;4(5):571-7.