MUC4 Recombinant Rabbit Monoclonal Antibody

Cytokeratin 19 is the smallest keratin and is exceptional since it widely lacks the non--helical tail domain typical for all other keratins. It may have evolved from keratinocyte keratins.

Cytokeratin 19 is expressed in most simple epithelia (excluding parenchymatous cells such as hepatocytes, pancreatic acinar cells, and renal proximal tubular cells), notably in various ductal epithelia, in small and large intestinal epithelium, in gastric foveolar epithelium, and in mesothelium. Furthermore, it is present in most cells of pseudostratified epithelia and urothelium as well as in basal cells of non-keratinizing stratified squamous epithelium. In carcinomas, cytokeratin 19 is widely expressed in both adenocarcinomas and squamous cell carcinomas and therefore is not extensively used as an immunohistochemical marker for carcinoma subtyping.

Cytokeratin 19 is not expressed in most hepatocytes, therefore cytokeratin 19 is useful in the identification of liver metastasis and can be used in a panel with Hepatocyte Specific Antigen.

Specifications

Catalog No.
BX50117
Clone No.
BP6121
Application
IHC-P
Subcellular location
Cytoplasmic
Control
Cervix Carcinoma Tissue
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Recombinant fragment corresponding to HumanMUC4 with aa1500-2000 was used as an immunogen.

Reference

1.Svetlana Kovalenko, et al. Adv Respir Med. 2017;85(1):3-7.

2.Chebib, et al . International Journal of Surgical Pathology. 2014;23(2), 144–148.

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