GFAP Recombinant Rabbit Monoclonal Antibody

GFAP (Glial fibrillary acidic protein) is an intermediate filament protein. The protein is the smallest (8 nm) of the intermediate filament proteins with a molecular weight of about 50 kDa.

In the central nervous system, GFAP is expressed in astrocytes and ependymal cells but not in other glial cells. However, immature oligodendrocytes and immature choroid plexus cells may be GFAP positive. In the peripheral nervous system enteric Schwann cells and satellite cells of human sensory ganglia express GFAP. Outside the nervous system, GFAP is seen in myoepithelial cells and chondroblasts. In tumor tissues, astrocytoma, ependymoma, glioblastoma, and oligodendroglioma are almost always positive. Plexus carcinoma, ganglioglioma and primitive neuroectodermal tumors (PNET: neuroblastoma a.o.) express GFAP to a varying extent. Schwannoma and neurofibroma frequently express GFAP. Chondroma, chondrosarcoma and pleomorphic adenoma are also GFAP positive in most cases. A few carcinomas (especially from lung and breast) may express GFAP in paraganglioma GFAP may be detected in sustentacular cells.

GFAP is used to differentiate astrocytoma from non-glial cell tumors.

Specifications

Catalog No.
BX50056
Clone No.
BP6061
Application
IHC-P
Subcellular location
Cytoplasm
Control
Astrocytoma
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to GFAP residues within aa332-432 of GFAP was used as an immunogen.

Reference

1.McLendon RE, et al. Brain Tumor Pathol. 2002;19(2):51-8. Review.
2.Matyja E, et al. Folia Neuropathol. 2001;39(1):19-26.

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