Antigen Ki-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Furthermore, it is associated with ribosomal RNA transcription.Ki-67 was present in the nuclei of cells in the G1, S, and G2 phases of the cell division cycle as well as in mitosis. Quiescent or resting cells in the G0 phase did not express the Ki-67 antigen.Ki-67 protein was used as diagnostic tools in different types of neoplasms because it was present in all proliferating cells (normal and tumor cells) and was an excellent operational marker to determine the growth fraction of a given cell population.
Specifications
Catalog No.
BX50040
Clone No.
BP6045
Application
IHC-P
Subcellular location
Nucleus
Control
Tonsil
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to Ki-67 residues within aa1000-1100 of Ki-67 was used as an immunogen.
Reference
1.Scholzen T, et.al, J Cell Physiol. 2000 Mar;182(3):311-22.
2.Inwald EC, et.al, Breast Cancer Res Treat. 2013 Jun;139(2):539-52.