ERG Recombinant Rabbit Monoclonal Antibody

ERG (ETS-related gene) is a proto-oncogene, a member of the ETS family of transcription factors. The ERG gene encodes for a nuclear protein, also called ERG, which is involved in hematopoietic and endothelial development. ERG remains constitually expressed in endothelial cells in blood and lymphatic vessels, and in bone marrow stem cells.
ERG is expressed in virtually all endothelial neoplasms including haemangioendothelioma, angiosarcoma and Kaposi sarcoma. ERG is overexpressed secondary to gene rearrangement in cases of prostate adenocarcinoma, gastrointestinal stromal tumour, synovial sarcoma, meningioma, epithelioid sarcoma, malignant rhabdoid tumour, acute myeloid leukemia and blastic extramedullary myeloid tumor, and rarely Ewing sarcoma / primitive peripheral neuroectodemal tumour, chondrosarcoma, osteosarcoma, and rhabdomyosarcoma.
For the identification of endothelial differentiation ERG seems more sensitive and specific than any other marker. Moreover, the interpretation is often easier due to the nuclear reaction, which also allows for double stains with cytoplasmic markers like podoplanin. Among carcinomas, ERG is highly specific for prostate, while the sensitivity is moderate.

Specifications

Catalog No.
BX50123
Clone No.
BP6127
Application
IHC-P
Subcellular location
Nucleus
Control
Appendix
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to residues within aa450 to C-terminus of ERG was used as an immunogen.

Reference

1.Miettinen M. Histopathology. 2014 Jan;64(1):101-18. 

2.Stockman DL, Mod Pathol. 2014 Apr;27(4):496-501. 

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