PAX-2 is a member of the PAX family of transcription factors that, together with PAX-8, is involved in the regulation of the organogenesis of the kidney and the Müllerian system.Among the non-neoplastic tissue, PAX-2 was expressed in glomerular parietal epithelial cells, renal collecting duct cells, atrophic renal tubular cells, epithelial cells of ovarian surface, fallopian tube, endocervix, endometrium. Among the primary neoplasms, PAX-2 was mainly noted in renal cell carcinoma, carcinomas of Müllerian origin, nephrogenic adenomas.Recent investigations have indicated that PAX-2 could serve as a useful immunohistochemical marker that can assist in the diagnosis of epithelial tumors of the kidney, as well as some gynecologic (Müllerian) neoplasms.
Specifications
Catalog No.
BX50039
Clone No.
BP6044
Application
IHC-P
Subcellular location
Nucleus
Control
Kidney
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to PAX-2 residues within aa300-400 of PAX-2 was used as an immunogen.