CD14 is receptor for endotoxin and apoptotic cells. It is expressed by monocytes/histiocytes, Langerhans' cells, follicular dendritic reticulum cells, neutrophils (weakly), and endothelial cells of the liver sinusoids.
CD14 is detected in myeloid leukaemias with monoblastic/monocytic differentiation, and in histiocytic neoplasms like histiocytic lymphoma, Langerhans' cell histiocytosis and giant cell tumour. In cultures, a subpopulation of Kaposi sarcoma cells express CD14.
In differential diagnosis, CD14 is more specific than CD68 in the identification of monocytes/histiocytes and associated neoplasias.
Specifications
Catalog No.
BX50106
Clone No.
BP6111
Application
IHC-P
Subcellular location
Membrane
Control
Appendix
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to residues within aa1-100 of Podoplanin was used as an immunogen.