Liver cancer
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Arginase-1 Recombinant Rabbit Monoclonal Antibody
Argininase 1 (ARG-1) is a new hepatocyte marker and a key enzyme in the liver urea cycle. It is well expressed in normal hepatic nuclei, but not in other normal tissues, and is highly expressed in hepatocellular carcinoma with different degrees of differentiation. The better the differentiation is, the higher the positive rate is, and it is superior to HepPar 1 in poorly differentiated hepatocellular carcinoma. It is more sensitive than AFP and HepPar 1 in the diagnosis of hepatocellular carcinoma, and is often used in combination with Glypican3 for hepatocellular carcinoma and metastatic carcinoma. Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia.
Specifications
- Catalog No.
- BX50180
- Clone No.
- BP6158
- Application
- IHC-P
- Subcellular location
- Cytoplasm, Nuclears
- Control
- Liver cancer
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide within Human Liver Arginase aa 300- 400. The exact sequence is proprietary.
Reference
1. Azambuja, J. H., etal. Int. J. Mol. Sci. 2020, 21, 3990.
2. Chen DA, et al. J Clin Pathol 2020;0:1–4.
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