Spleen
Tonsil
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CD68 Recombinant Rabbit Monoclonal Antibody
CD68 is a highly glycosylated transmembrane protein which is mainly located in lysosomes. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions.CD68 is detected in different types of macrophages of monocyte lineage and also reacts with myeloid precursor cells in the bone marrow. Positivity is seen in Kupffer cells and histiocytes in normal lymphoid tissue, but also mast cells and microglia. In tumor tissues, it is detected in fibrous-histiocytic tumors, some epithelial neoplasms, epithelioid cells of some malignant melanomas.CD68 may be useful for the identification of myelomonocytic and histiocytic tumors.
Specifications
- Catalog No.
- BX50031
- Clone No.
- BP6036
- Application
- IHC-P
- Subcellular location
- Membrane/Cytoplasm
- Control
- Spleen
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide corresponding to CD68 residues within aa100-200 of CD68 was used as an immunogen.
Reference
1.Kunz-Schughart LA, et.al, Verh Dtsch Ges Pathol. 2003;87:215-23.
2.Sachdev R, et.al, J Cutan Pathol. 2006 May;33(5):353-60.
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