Tonsil
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CTLA-4 Recombinant Rabbit Monoclonal Antibody
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 expression is induced on the surface of T cells after CD28 binding and activation, and is constitutively expressed on T-regulatory cells, acting as an immune checkpoint inhibitor, downregulating T cell activity. CTLA-4 primarily inactivates T-cell activity by competing with the CD28 costimulatory molecule. CD28 and CTLA-4 share the identical ligands of CD80 and CD86 on antigenpresenting cells; and thus CTLA-4 competes with CD28 function in T-cell survival, proliferation, and recruitment.
Specifications
- Catalog No.
- BX50210
- Clone No.
- BP6187
- Application
- IHC-P
- Subcellular location
- Membrane
- Control
- Tonsil
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide within Human CTLA-4.
Reference
1. Buchbinder EI, McDermott DF. Clinical Therapeutics. 2015; 37:755-63.
2. Scalapino KJ, Daikh DI. Immunol Rev. 2008 Jun;223:143-55.
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