The SOX2 gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors. SOX2 is expressed in multipotent neuronal stem cells, and may aid to identify cells that are capable of self-renewal and multipotent differentiation. SOX2 has been shown to be a negative prognostic factor and associated with aggressive phenotypes in breast, head and neck, gastric, colorectal and bladder cancers. In small cell lung cancers, SOX2 was also correlated with a poor prognosis. Conversely, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and was shown to be an independent positive prognostic marker.
Specifications
Catalog No.
BX50119
Clone No.
BP6123
Application
IHC-P
Subcellular location
Nucleus
Control
Lung Squamous Cell Carcinomas
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to residues within aa1-100 of Human SOX2 was used as an immunogen.
Reference
1.Yang F, et al. Int J Clin Exp Pathol. 2013 Nov 15; 6 (12):2846-54.
2.Wilbertz T, et al. Mod Pathol. 2011 Jul; 24 (7):944-53.