Kidney
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SDHB Recombinant Rabbit Monoclonal Antibody
Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.
Specifications
- Catalog No.
- BX50182
- Clone No.
- BP6160
- Application
- IHC-P
- Subcellular location
- Cytoplasm
- Control
- Kidney
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide corresponding to residues in Human SDHB was used as an immunogen.
Reference
1. Chang HC et al. Redox Biol 20:321-333 (2019).
2. Her YF et al. PLoS One 10:e0127471 (2015).
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