Colon Carcinoma
Graded Large Cell Lymphoma
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CD25 Recombinant Rabbit Monoclonal Antibody
CD25, or interleukin 2 (IL2) receptor alpha (IL2RA), and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (CD25) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble CD25 has been isolated and determined to result from extracellular proteolyisis. CD25 (the p55 chain of the interleukin-2 receptor) is a marker of activation for a number of cell types, including T cells, B cells, and macrophages. It also appears to be a reliable immunohistochemical marker for the discrimination of neoplastic from normal/reactive mast cells, with potential as a diagnostic tool in systemic mastocytosis. CD25 is also expressed on hairy cell leukemia.
Specifications
- Catalog No.
- BX50116
- Clone No.
- BP6120
- Application
- IHC-P
- Subcellular location
- Membrane
- Control
- Colon Carcinoma Tissue
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Recombinant fragment corresponding to Human IL-2 Receptor alpha with aa1-250 was used as an immunogen.
Reference
1.N.A. Azab, et al. Clinical Immunology. 2008 127(2):151–157.
2.Zhang B, et al. Ann Rheum Dis 2008;67:1037-1040.
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