PSA Recombinant Rabbit Monoclonal Antibody

Prostate-specific antigen (PSA) is a single-chain glycoprotein of 237 amino acids containing approximately 8% carbohydrate. It is a serine protease produced almost exclusively by prostatic epithelial cells.

Immunohistochemically PSA is expressed in the highly specialized apically-superficial layer of female and male secretory cells of the prostate gland, and is readily demonstrated in adenocarcinomas of the prostate in about 99% of the cases. There is a correlation between malignancy grade and intensity of staining, high grade carcinomas displaying weaker expression. About 1% of poorly differentiated carcinomas have been negative for PSA.

Due to the high specificity of PSA for prostatic glandular epithelium, it is very useful in identifying prostatic carcinoma in the prostate and in the adjacent organs often affected by epithelial malignancies, i.e. rectum and urinary bladder. PSA may be used in a panel together with NKX3.1 and Prostein, which are at least as sensitive and slightly more specific than PSA.

Specifications

Catalog No.
BX50038
Clone No.
BP6043
Application
IHC-P
Subcellular location
Cytoplasm
Control
Prostate cancer
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to PSA residues within aa150-250 of PSA was used as an immunogen.

Reference

1.Ward AM, et.al, Ann Clin Biochem 2001; 38: 633-651.
2.ACS Aguiar , et.al, Histol Histopathol (2000) 15: 131-142.

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