Villin is a 93 kDa calcium-regulated, actin-binding protein that plays a role in regulating actin filament assembly. It is a major constituent in the microvilli, which compose the brush border of epithelial cells forming absorptive surfaces of the intestinal and renal proximal tubular epithelia. In normal human tissue, villin is expressed by a limited number of simple epithelia of the gastrointestinal and urogenital tract. In tumor tissue, it is always expressed in colorectal cancer, hepatocellular carcinoma, endometrium cancer, as well as cancers of ovary and lung.Villin is a useful aid for classification of primary and metastatic colorectal carcinomas.
Specifications
Catalog No.
BX50061
Clone No.
BP6066
Application
IHC-P
Subcellular location
Cytoplasm
Control
Colon
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to Villin residues within aa600-700 of Villin was used as an immunogen.
Reference
1.R Moll et al. Histochem Cell Biol (2008) 129:705–733.
2.R Moll et al. Cell, Vol. 31, 1 l-24, November 1982.