Seminoma
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Oct3/4 Recombinant Rabbit Monoclonal Antibody
OCT-4, also known as OTF3 or POU5F1, is a member of the POU family of transcription factors, involved in the regulation of pluripotency during normal development and is detectable in embryonic stem and germ cells. It can specifically bind to the octamer motif (5'-ATTTCAT-3'), and it is critical for the self-renewal of embryonic stem cells. OCT-4 is a key regulator of selfrenewal in embryonic stem cells; its expression is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior such as tumor recurrence or resistance to therapies. OCT-4 is a sensitive and specific marker for germ cell tumors.
Specifications
- Catalog No.
- BX50186
- Clone No.
- BP6164
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Seminoma
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide corresponding to residues in Human Oct-3/4 was used as an immunogen.
Reference
1. Zhang S et al. Nucleic Acids Res 47:4449-4461 (2019).
2. Chang YC et al. Cell Death Dis 11:195 (2020).
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