Tonsil
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Tim-3 Recombinant Rabbit Monoclonal Antibody
T cell Ig- and mucin-domain-containing molecules (TIMs) are a family of transmembrane proteins expressed by various immune cells. TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer, and tumor-infiltrating T cells that coexpress PD-1 and TIM-3 exhibit the most severe exhausted phenotype. TIM-3 is an inhibitory molecule that is induced following T cell activation.Tumor-infiltrating dendritic cells (DCs) also express TIM-3.
Specifications
- Catalog No.
- BX50205
- Clone No.
- BP6182
- Application
- IHC-P
- Subcellular location
- Membrane
- Control
- Tonsil
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide corresponding to Human Tim-3 protein was used as an immunogen. The exact sequence is proprietary.
Reference
1.Huang, Y.H. et al. (2015) Nature 517, 386-90.
2. Monney, L. et al. (2002) Nature 415, 536-41.
3. Chiba, S. et al. (2012) Nat Immunol 13, 832-42.
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