Procalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of about 13 kDa. PCT itself has no known hormonal activity. PCT belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 amino acids from the N-terminus. PCT undergoes successive cleavages to form three molecules: N-terminal fragment (55 a.a.), calcitonin (32 a.a.) and katacalcin (21 a.a.).
Specifications
Catalog No.
BX50260
Clone No.
BP6237
Application
IHC-P
Subcellular location
Cytoplasm
Control
Thyroid
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
A synthetic peptide corresponding to the N-term of Procalcitonin was used as an immunogen.
Reference
1. Kremmer E et al. Anal Bioanal Chem 402:989-95 (2012).
2. Llewelyn MJ, et al. J Antimicrob Chemother 2022 Feb 08.