Thymus
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CD1a Recombinant Rabbit Monoclonal Antibody
CD1a is a member of the family group 1 CD1 proteins (CD1a, CD1b, and CD1c), which share the capacity to present microbial lipid antigens to cells.
CD1a is expressed predominantly on Langerhans cells (LCs), it can be expressed by T-cells under certain conditions. Immature thymocytes express CD1a, as do some T-cells involved in neoplastic conditions such as pre-lymphoblastic lymphomas/leukemias and follicular dendritic cell sarcoma.
CD1a expression on pathogenic Langerhans cells (LCs) in LCH is regarded as a hallmark of this disease and may as a potential target for future therapeutic strategies against inflammatory skin diseases.
CD1a is expressed predominantly on Langerhans cells (LCs), it can be expressed by T-cells under certain conditions. Immature thymocytes express CD1a, as do some T-cells involved in neoplastic conditions such as pre-lymphoblastic lymphomas/leukemias and follicular dendritic cell sarcoma.
CD1a expression on pathogenic Langerhans cells (LCs) in LCH is regarded as a hallmark of this disease and may as a potential target for future therapeutic strategies against inflammatory skin diseases.
Specifications
- Catalog No.
- BX50050
- Clone No.
- BP6055
- Application
- IHC-P
- Subcellular location
- Membrane
- Control
- Thymus
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide corresponding to CD1a residues within aa1-100 of CD1a was used as an immunogen.
Reference
1.Hunger RE, et.al, J Clin Invest. 2004 Mar;113(5):701-8.
2. Ji Hyung Kim, et.al, Nature Immunology 17 (10) , pp. 1159-1166
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