Dedifferentiated liposarcoma
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CDK4 Recombinant Rabbit Monoclonal Antibody
Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle. It is essential for the G1- to S-phase transition during the cell cycle and its expression is primarily controlled at the transcriptional level (PMID:17253961). CCND1- CDK4 axis is not only critical in glial tumor cells but also in stromal-derived cells in the surrounding tumor microenvironment that are vital to sustain tumor outgrowth (PMID:21844184).
Specifications
- Catalog No.
- BX50253
- Clone No.
- BP6230
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Dedifferentiated liposarcoma
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle. It is essential for the G1- to S-phase transition during the cell cycle and its expression is primarily controlled at the transcriptional level (PMID:17253961). CCND1- CDK4 axis is not only critical in glial tumor cells but also in stromal-derived cells in the surrounding tumor microenvironment that are vital to sustain tumor outgrowth (PMID:21844184).
Reference
1. Ma L et al. Oncotarget 8:4125-4135 (2017).
2. Lv XJ et al. Oncol Rep N/A:N/A (2016).
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