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MGMT Recombinant Rabbit Monoclonal Antibody
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Specifications
- Catalog No.
- BX50240
- Clone No.
- BP6217
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Appendix
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- A synthetic peptide corresponding to residues on the N-terminus of human MGMT was used as an immunogen.
Reference
1. Bobola, M.S. et al. (2005) Clin. Cancer Res. 11, 2747-2755.
2. Pollack, I.F. et al. (2006) J. Clin. Oncol. 24, 3431-3437.
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