Cervical intraepithelial neoplasias
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p16 Recombinant Mouse Monoclonal Antibody
The progression of cells through the cell cycle is regulated by a family of protein kinases known as cyclin-dependent kinases (Cdks). The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. Moreover, the gene encoding p16 INK4A exhibits a high frequency of homozygous deletions and point mutations in established human tumor cell lines.
Specifications
- Catalog No.
- BX50261
- Clone No.
- BPM6238
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Cervical intraepithelial neoplasias
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Full length recombinant p16 INK4A of human origin was used as an immunogen.
Reference
1. Romagosa, C. et al. (2011) Oncogene 30, 2087-97.
2. LaPak, K.M. and Burd, C.E. (2014) Mol Cancer Res 12, 167-83.
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