p16 Recombinant Mouse Monoclonal Antibody

The progression of cells through the cell cycle is regulated by a family of protein kinases known as cyclin-dependent kinases (Cdks). The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. Moreover, the gene encoding p16 INK4A exhibits a high frequency of homozygous deletions and point mutations in established human tumor cell lines.

Specifications

Catalog No.
BX50261
Clone No.
BPM6238
Application
IHC-P
Subcellular location
Nucleus
Control
Cervical intraepithelial neoplasias
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Full length recombinant p16 INK4A of human origin was used as an immunogen.

Reference

1. Romagosa, C. et al. (2011) Oncogene 30, 2087-97.
2. LaPak, K.M. and Burd, C.E. (2014) Mol Cancer Res 12, 167-83.

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