p21 Recombinant Rabbit Monoclonal Antibody
p21, also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 (6p21.2). The p21 protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1.p21 is expressed in all adult human tissues. In tumors, the expression of p21 has been studied by immunohistochemical methods in a wide range of human tumors, such as gastric carcinoma, non-small cell lung carcinoma, and thyroid carcinoma. The expression of p21 is associated with favorable prognosis in various tumors.
Specifications
- Catalog No.
- BX50063
- Clone No.
- BP6068
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Cervix cancer
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide corresponding to p21 residues within aa1-100 of p21 was used as an immunogen.
Reference
1.Komiya T et al. Clin Cancer Res. 1997 Oct;3(10):1831-5.
2.Natsugoe S et al. Clin Cancer Res. 1999 Sep;5(9):2445-9.
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