Cytokeratin 1 Recombinant Rabbit Monoclonal Antibody

Cytokeratin 1 may regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1).Defects in Cytokeratin 1 are a cause of bullous congenital ichthyosiform erythroderma (BCIE); also known as epidermolytic hyperkeratosis (EHK) or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.In diagnostic pathology, immunohistochemical detection of cytokeratin 1 is usually used to label squamous, ductal and complex epithelia combined with other high molecular weight cytokeratins such as cytokeratins 5, 10 and 14. Results aid in the classification of prostatic adenocarcinoma and in the classification of neoplastic tissue as carcinoma of epithelial origin.