p53 Recombinant Mouse Monoclonal Antibody

p53 has been observed to act as both as a tumor-suppressor and transcription factor. By binding to DNA, the normal p53 negatively regulates cell growth and division. In case of DNA damage, p53 arrests the cell cycle until repair has taken place. In case repair is not possible, p53 induces apoptosis. p53 acts a two checkpoints in the cell cycle, between G1 and S, and between G2 and M, respectively.

Specifications

Catalog No.
BX50190
Clone No.
BPM6168
Application
IHC-P
Subcellular location
Nucleus
Control
Colon cancer
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Recombinant human wild type p53 protein was used as an immunogen.

Reference

1. Wang L et al. IUBMB Life 71:45-56.
2. Dang X et al. Chem Biol Interact 300:82-90.

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