Von Willebrand Factor (VWF) Recombinant Rabbit Monoclonal Antibody
Human von Willebrand factor (VWF,or factor VIII-related antigen) is a 309 kDa multimeric plasma glycoprotein, important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Von Willebrand factor also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand factor is synthesized by endothelial cells and is reported to be expressed in a number of tumors of vascular origin. IHC results aid in the classification of acute myeloid leukemia FAB type M7, angiosarcoma and epithelioid hemangioendothelioma.
Specifications
Catalog No.
BX50079
Clone No.
BP6084
Application
IHC-P
Subcellular location
Cytoplasm
Control
Cervix
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to residues within aa1150-1250 of von Willebrand factor was used as an immunogen.
Reference
1.Weidner N, Semple JP, Welch WR, Folkman J. N Engl J Med 1991,324:1-8.
2.Obermair A, Wanner C, Bilgi S, Speiser P, et al. Am J Obstet Gynecol 1998 Feb;178(2):314-319.