Tonsil
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Survivin Recombinant Rabbit Monoclonal Antibody
"Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy. Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division. This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase. Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth.
Survivin is expressed in tonsil, testis, fetal tissue and all kinds of tumors. Survivin is not thought to be expressed in adult terminally differentiated cells, but recent evidence has also shown expression on adult vascular endothelial cells, T cells, red blood cells, and hematopoietic progenitor cells.
Survivin is mainly used in the diagnosis of hepatocellular carcinoma, endometrial carcinoma and squamous cell carcinoma."
Survivin is expressed in tonsil, testis, fetal tissue and all kinds of tumors. Survivin is not thought to be expressed in adult terminally differentiated cells, but recent evidence has also shown expression on adult vascular endothelial cells, T cells, red blood cells, and hematopoietic progenitor cells.
Survivin is mainly used in the diagnosis of hepatocellular carcinoma, endometrial carcinoma and squamous cell carcinoma."
Specifications
- Catalog No.
- BX50282
- Clone No.
- BP6259
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Tonsil
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide. This information is proprietary to Biolynx.
Reference
1. lie, R.A. et al. (2000) Cancer Res. 60, 2805-2809.
2. Grossman, D. et al. (2001) Proc. Natl. Acad. Sci. USA 98, 635-640.
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