Cervical Cancer
Lung Cancer
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Topoisomerase Ⅱ-α Recombinant Rabbit Monoclonal Antibody
The topoisomerase II-α isoform is a 170 kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis.Topoisomerase II-α is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers.Decreased expression of Topoisomerase II-α is the predominant mechanism of resistance to several chemotherapeutic agents.
Specifications
- Catalog No.
- BX50011
- Clone No.
- BP6016
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Esophagus
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide corresponding to Topo II α residues within aa1431-1531 of Topo II α was used as an immunogen.
Reference
1.Lynch BJ, et al, Hum Pathol. 1997 Oct;28(10):1180-8
2.Gupta D, et al, Appl Immunohistochem Mol Morphol. 2001 Sep;9(3):215-21.
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