Liver cancer
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AFP Recombinant Rabbit Monoclonal Antibody
Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the mammalian fetal liver, yolk sac, and GI tract. While AFP expression in adult cells is low, it is aberrantly expressed in adult liver cancer cells. The tumor suppressor gene p53 and βcatenin are both involved in the regulation of AFP expression. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Research studies have shown that elevated serum AFP levels are predictive of hepatocellular carcinoma.
Specifications
- Catalog No.
- BX50267
- Clone No.
- BP6244
- Application
- IHC-P
- Subcellular location
- Cytoplasm
- Control
- Liver cancer
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide. This information is proprietary to Biolynx.
Reference
1. Meier, V. et al. (2006) Comp Hepatol 5, 2.
2. Peng, S.Y. et al. (2004) Int J Cancer 112, 44-50.
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