Melanoma
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PRAME Recombinant Rabbit Monoclonal Antibody
PRAME (preferentially expressed antigen in melanoma) is a cancer/testis antigen not normally expressed in any tissues except testis, but is upregulated in tumors. PRAME is expressed in melanoma cells and is recognized by cytolytic T-cells. It is also upregulated in other diseases, such as synovial sarcoma, NSCLC, and breast cancer, where it is thought to contribute to tumorigenesis and metastasis. PRAME is also highly expressed in liquid tumors such as AML and can be predictive of clinical outcome in some circumstances.
Specifications
- Catalog No.
- BX50271
- Clone No.
- BP6248
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Melanoma
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Recombinant protein fragment of human PRAME was used as an immunogen.
Reference
1. Qin, Y.Z. et al. (2017) Oncol Lett 13, 2823-2830.
2. Lura, K. et al. (2017) Hum Pathol 61, 130-139.
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