HLA-G (HLA-G histocompatibility antigen, class I, G) is a non-classical MHC molecule expressed by trophoblasts in placenta, thymic epithelial cells, and some tumors. Alternative splicing leads to generation of at least six isoforms, four that are transmembrane proteins and two that are soluble. It is an inhibitory molecule involved in immune tolerance and escape, originally studied for its role in maternal tolerance of the fetus during pregnancy. HLA-G binds ILT2, ILT4, and KIR2DL4, playing a role in the regulation of natural killer, T, and monocyte/macrophage cells. Its involvement in evasion of immune response makes it a potential target for immunotherapy.
Specifications
Catalog No.
BX50270
Clone No.
BP6247
Application
IHC-P
Subcellular location
Membrane
Control
Choriocarcinoma
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Recombinant protein fragment of human HLA-G was used as an immunogen.
Reference
1. Curigliano, G. et al. (2013) Clin Cancer Res 19, 5564-71.
2. Shiroishi, M. et al. (2003) Proc Natl Acad Sci U S A 100, 8856-61.