Lymphoma
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LAG-3 Recombinant Rabbit Monoclonal Antibody
Lymphocyte activation gene 3 (LAG-3, CD223) is an immune checkpoint control protein that negatively regulates T cells and immune responses. A CD4-like member of the Ig superfamily, LAG3 contains an extracellular IgV and three IgC domains, a transmembrane domain, and a short cytoplasmic region. LAG3 is primarily expressed by activated CD4+ T cells, CD8+ T cells, Tregs and NK cells, where it's activated by MHC Class II molecules, its only known ligand. While it was initially shown to activate Treg cells, LAG3 can also inhibit CD8+ T cells.
Specifications
- Catalog No.
- BX50215
- Clone No.
- BP6192
- Application
- IHC-P
- Subcellular location
- Membrane
- Control
- Lymphoma
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide within Human LAG-3.
Reference
1. Matsuzaki, J. et al. (2010) Proc Natl Acad Sci U S A 107, 7875-80.
2. Woo, S.R. et al. (2012) Cancer Res 72, 917-27.
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