Pax genes are a family of developmental control genes that encode nuclear transcription factors and have been implicated in the control of mammalian development. PAX-5 is a marker for B-cells, including B-lymphoblastic neoplasms and maturation stage. It is found in most cases of mature and precursor B-cell non-Hodgkin lymphomas/leukemias. In approximately 97% of cases of classic Hodgkin lymphoma, ReedSternberg cells express PAX-5. The antibody is a useful tool for the identification of pro, pre, and mature B cells and for classification of lymphomas and subclassification of classic Hodgkin's lymphoma and anaplastic large cell lymphoma of the T and null-cell type.
Specifications
Catalog No.
BX50195
Clone No.
BPM6172
Application
IHC-P
Subcellular location
Nucleus
Control
Tonsil
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to residues within aa300 to aa400 of PAX-5 was used as an immunogen.
Reference
1. Abdelrasoul H et al. Sci Rep 8:1327 (2018).
2. Hijano DR et al. Sci Rep 8:11034 (2018).