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p-RIPK1(S166) Recombinant Rabbit Monoclonal Antibody
Receptor-interacting serine/threonine-protein kinase 1 is a serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. RIPK1 is phosphorylated at several sites within the kinase domain that are sensitive to Nec-1, including Ser14, Ser15, Ser161, and Ser166.
Specifications
- Catalog No.
- BX60008
- Clone No.
- YJY-1-5
- Application
- WB、IP、IF/ICC、IHC-Fr
- Volume
- 100μl/vial
- Dilution
- WB：1:1,000 - 1:2,000；IHC-P：1:100 - 1:500；IF/ICC：1:100 - 1:500；IHC-Fr：1:100 - 1:500；IP：1:50 - 1:500
- Immunogen
- A synthetic phospho-peptide corresponding to residues surrounding serine 166 of Mouse RIPK1 protein was used as the immunogen.
Reference
1.Xu et al., TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging, Cell, 174, 1–15, 2018.
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