GATA binding protein 3 or GATA-3, is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types. GATA-3 is one of the three genes mutated in 10% of breast cancers. Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ cancer and luminal androgen responsive cancer in ER-/AR+ tumors. It is highly coexpressed with FOXA1 and serves as negative predictor of basal subtype and HER-2 and is also considered a strong predictor of taxane and platin salts insensitivity.
Specifications
Catalog No.
BX50252
Clone No.
BP6229
Application
IHC-P
Subcellular location
Nucleus
Control
Breast cancer
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide. This information is proprietary to Biolynx.
Reference
1. Voduc D, et al. Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):365-73.
2. Miettinen M, et al. Am J Surg Pathol. 2014 Jan; 38(1): 13–22.