Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.
Specifications
Catalog No.
BX50182
Clone No.
BP6160
Application
IHC-P
Subcellular location
Cytoplasm
Control
Kidney
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to residues in Human SDHB was used as an immunogen.
Reference
1. Chang HC et al. Redox Biol 20:321-333 (2019).
2. Her YF et al. PLoS One 10:e0127471 (2015).